Showing posts with label uveodermatalogical syndrome. Show all posts
Showing posts with label uveodermatalogical syndrome. Show all posts
Sunday, December 9, 2012
DECEMBER 9, 2012
Checking in... need to post updates to show how well Corky is doing today... will post upadates soon. Meantime, email me for any questions at: chris.wallace@cox.net
Thursday, May 10, 2012
May 10, 2012 UPDATE
Corky had minor surgery early Feb to remove a cyst inside his lip and right
after that he had uncontrollable diarrhea which took me almost 2 months to
correct. His energy is still high even though you can feel all his bones but
he's doing great now and putting the weight back on and is a healthy happy boy. His
disease has also been in remission for almost 6 months since the last minor
flare up and he's been down to a maintenance level of only 10mg pred EOD plus 50mg azathioprine once daily, thyroxine, niacinamide, and adenysol 225mg daily.
Who knows why the terrible diarrhea started (maybe because of the long-term
meds?) but I did all the right things... fasting, bland diet, probiotics, GI
gels, cutting way back on his Taste of the Wild kibble and can, etc. It was
frustrating scarry. Then a friend told me about The Honest Kitchen "Perfect Form"
supplement and that stuff started to work almost instantly. But it wasn't until
I concluded he had grown intolerant to TOW salmon/sweet potato, even though he'd
eaten it every day for the past 2.5 years (since onset of the disease... I was
afraid to change it and rock the boat). So I fasted him again and then fed him
homemade boiled potatoes (white rice went through him like water) and bland
poached cod along with "Perfect Form" and stopped the kibble entirely. Finally,
we started to see some solid poops and less mud pies. This is after about 7
weeks of uncontrollable diarrhea.
So, with that success, I decided to try The Honest Kitchen foods and gradually added their "Preference" formula to the homemade whitefish/potatoes and "PF". Then, with
great relief, normal poops started coming out and I didn't have to wash any more
messy butts. It has been uphill since with solid normal poops. Corky loves his new diet and I put Lulu
on it too, only she gets canned Wellness chicken with hers. I add olive oil to
Cork's because the "Preference" is very lowfat. The weight is slowly coming back
on and his coat is looking much better. Whew!
Next I'm going to try The Honest Kitchen formula with fish so I don't have to
keep cooking fresh fish but might mix it with the "Preference" (base formula)
because the "Zeal" is a whopping 35% protein and I'm afraid to change Corky's
chemistry too much because of his disease. His vet believes in lower protein
diets around 20 - 28%.
BTW, TOW foods are on the recent recall lists but not for our states.
after that he had uncontrollable diarrhea which took me almost 2 months to
correct. His energy is still high even though you can feel all his bones but
he's doing great now and putting the weight back on and is a healthy happy boy. His
disease has also been in remission for almost 6 months since the last minor
flare up and he's been down to a maintenance level of only 10mg pred EOD plus 50mg azathioprine once daily, thyroxine, niacinamide, and adenysol 225mg daily.
Who knows why the terrible diarrhea started (maybe because of the long-term
meds?) but I did all the right things... fasting, bland diet, probiotics, GI
gels, cutting way back on his Taste of the Wild kibble and can, etc. It was
frustrating scarry. Then a friend told me about The Honest Kitchen "Perfect Form"
supplement and that stuff started to work almost instantly. But it wasn't until
I concluded he had grown intolerant to TOW salmon/sweet potato, even though he'd
eaten it every day for the past 2.5 years (since onset of the disease... I was
afraid to change it and rock the boat). So I fasted him again and then fed him
homemade boiled potatoes (white rice went through him like water) and bland
poached cod along with "Perfect Form" and stopped the kibble entirely. Finally,
we started to see some solid poops and less mud pies. This is after about 7
weeks of uncontrollable diarrhea.
So, with that success, I decided to try The Honest Kitchen foods and gradually added their "Preference" formula to the homemade whitefish/potatoes and "PF". Then, with
great relief, normal poops started coming out and I didn't have to wash any more
messy butts. It has been uphill since with solid normal poops. Corky loves his new diet and I put Lulu
on it too, only she gets canned Wellness chicken with hers. I add olive oil to
Cork's because the "Preference" is very lowfat. The weight is slowly coming back
on and his coat is looking much better. Whew!
Next I'm going to try The Honest Kitchen formula with fish so I don't have to
keep cooking fresh fish but might mix it with the "Preference" (base formula)
because the "Zeal" is a whopping 35% protein and I'm afraid to change Corky's
chemistry too much because of his disease. His vet believes in lower protein
diets around 20 - 28%.
BTW, TOW foods are on the recent recall lists but not for our states.
Wednesday, February 22, 2012
March 22, 2012 Update
Corky is still going strong.... will post update soon! Meantime, scroll down to "OLDER POSTS" tab (lower right corner) to view photos of disease since onset 2009.
Saturday, July 16, 2011
Definition repeat from older post:
Uveodermatological Syndrome:
Uveodermatological Syndrome (UDS) is an immune-mediated canine disease characterized by inflammation of the eye, depigmentation of skin and whitening of hair. Morbidity is related primarily to the eye inflammation, which can result in secondary ophthalmological disorders that lead to blindness. Treatment involves both topical and systemic immunosuppression. It is believed that UDS results from a genetic flaw, and as yet there is no cure.
Uveodermatological Syndrome is similar to the human Vogt-Koyanagi-Haradi Syndrome (VKH), was first described in 1977. Human VKH is characterized by uveitis (inflammation of the eye), poliosis (whitening of hair), vitiligo (depigmentation of skin) and a variety of neurological symptoms. Unlike VKH, however, UDS does not usually present with neurological symptoms. Because of the similarity of the two entities, UDS is sometimes referred to as VKH-like Syndrome or simply VKH. Although generally considered to be more common in Northern breeds, such as Akitas, Siberians and Samoyeds, there have been reports of the disease in a wide range of breeds, including the Australian Shepherd, Dachshund, Brazilian Fila dog.
Clinical Relevance: Some breeds in which uveodermatologic syndrome has been reported (eg, Siberian Huskies, Old English Sheepdogs, Australian Shepherds, and Shetland Sheepdogs) often have heterochromia irides. This case highlights the fact that dogs with asymmetric uveal pigmentation may have unilateral ocular changes; therefore, uveodermatologic syndrome should not be excluded as a differential diagnosis on the basis of unilateral clinical signs.
Here are links to good documentations of dogs with the disease:
http://www.dogbreedinfo.com/articles/vkhsyndrome.htm
http://www.samoyedhealthfoundation.org/diseases/uveodermatologic-syndrome-uds/living-with-uds-vkh
Uveodermatological Syndrome (UDS) is an immune-mediated canine disease characterized by inflammation of the eye, depigmentation of skin and whitening of hair. Morbidity is related primarily to the eye inflammation, which can result in secondary ophthalmological disorders that lead to blindness. Treatment involves both topical and systemic immunosuppression. It is believed that UDS results from a genetic flaw, and as yet there is no cure.
Uveodermatological Syndrome is similar to the human Vogt-Koyanagi-Haradi Syndrome (VKH), was first described in 1977. Human VKH is characterized by uveitis (inflammation of the eye), poliosis (whitening of hair), vitiligo (depigmentation of skin) and a variety of neurological symptoms. Unlike VKH, however, UDS does not usually present with neurological symptoms. Because of the similarity of the two entities, UDS is sometimes referred to as VKH-like Syndrome or simply VKH. Although generally considered to be more common in Northern breeds, such as Akitas, Siberians and Samoyeds, there have been reports of the disease in a wide range of breeds, including the Australian Shepherd, Dachshund, Brazilian Fila dog.
Clinical Relevance: Some breeds in which uveodermatologic syndrome has been reported (eg, Siberian Huskies, Old English Sheepdogs, Australian Shepherds, and Shetland Sheepdogs) often have heterochromia irides. This case highlights the fact that dogs with asymmetric uveal pigmentation may have unilateral ocular changes; therefore, uveodermatologic syndrome should not be excluded as a differential diagnosis on the basis of unilateral clinical signs.
Here are links to good documentations of dogs with the disease:
http://www.dogbreedinfo.com/articles/vkhsyndrome.htm
http://www.samoyedhealthfoundation.org/diseases/uveodermatologic-syndrome-uds/living-with-uds-vkh
Friday, July 8, 2011
July 6, 2011 CORKY TURNS 8!!!
HAPPY BIRTHDAY CORKY!!!!
Corky remains stable and happy and we have been enjoying a long remission of the disease... however the symptoms do try to sneak up at times and then I will increase the dosage of pred a bit following a gradual tapering until we are back to the EOD (every other day) routine. I watch for symptoms mainly of pigment recession around the eyerims, nose, and mouth and also for any squinting. When the black pigment starts to fade to pink, usually at the eye corners, I increase the dosage to 20mg prednisone for one day then decrease it to 15mg for the next two or three along with all the other meds until we get back to the EOD schedule.
Last eye exams were good and improved since we switched from regular prednisolone acetate drops to pred mild drops every other day. He only has to see the opthamologist every 4 months now. Cork's recent full body lab results showed normal ranges in all organs except now the liver is showing some steroids. This did not surprise the doctor but he had expected to see this kind of result many months ago as Corky has been under steroid therapy for 19 months. The doctor was simply amazed. I wondered if Cork's success can be credited to the long term use of the Veterinary Immune Tabs that have Transfer Factors and medicinal mushroom extracts. At any rate his thyroid is doing fine and overall Corky looks fantastic! His coat is thick and healthy, the black pigment around his face looks great, his musculature is great, paw pads have greatly improved, and even the limp is gone. As for the liver, we have added "SAMe" s-adenosyl 225mg/ milk thistle to his routine in order to protect the liver.
Here is Corky's current meds: Azathioprine 50mg once daily, niacinamide 500mg & doxycycline 100mg & SAMe 225mg & thyroxine .4mg twice daily. Prednisone 10mg or 12.5mg once every other day. Prednisolone mild acetate 12% eyedrops in both eyes once every other day. Genteal mild eyedrops twice daily. Veterinary Immune Tabs professional strength 2 tabs 4 times weekly. Taste of the Wild salmon/sweet potato kibble and spoonfuls of Naturals fish/sweet potato canned and/or fresh salmon, carrots, apple, treats. Also, to support his thyroid he gets 1 tsp organic kelp powder daily. Most important ingredient of all: unconditional endless LOVE!
During Corky's rehab for his front leg limp he swam many laps in the pool. The limp lasted about 6 months. Finally I restricted his daily walks to absolute minimum with no running but increased his swimming sessions. One day he suddenly stopped limping and hasn't limped since. Here he is going for a swim... fetching the ball in the long lap pool:
LUCKY BOY:
Wednesday, February 9, 2011
February 9, 2011 CORKY IS A SUCCESS CASE!
It has been well over a year since Corky's official diagnosis of UVD and today he is looking and feeling great. His hair has mostly all grown back and it feels healthy and soft as it had drastically thinned back in September when his thyroid level dropped too low due to medication side effects. The pigment around his eyes, nose, and lips have stayed normal black for almost four months now.
We must be reminded of how serious and extreme Corky's symptoms were back in December 2009 (scroll down to earlier posts) and the long rollercoaster ride it took to finally get the disease into a sustained remission. Looking back we have endured two minor flareups and one major flareup in July 2010 which took a dreaded extended course of high dosage prednisone to bring the disease back under control. In addition to the numerous side effects from this episode, including hairloss and lowered thyroid, Corky had to undergo a major dental surgery in early October due to a deceptive cracked tooth which led to an abscessed carnasial molar that had be removed. This of course triggered his autoimmune UVD syndrome symptoms but after the surgery it calmed down and, to our great relief, has stayed in remmission ever since. His recent lab results came back healthy normal aside from his T-4 which seems to be oscillating between 1.7 and .5 so we have increased the thyroxine to .4mg twice daily. In addition to the thyroxine he is on a maintenance of prednisone every other day at 10mg alternated with 15mg EOD with a day of no pred inbetween. Niacinamide 500mg and Doxycycline 100mg twice daily. Azathioprine 50mg once daily. Prednisolone Acetate eyedrops twice daily. Other supplements include organic kelp powder and Veterinary Immune Tabs (professional strength) two tabs daily four times weekly. Taste of the Wild salmon/sweet potato grain free kibble and canned wet food for med adminstrating.
The good news is that Corky is happy and enjoying life as we are thoroughly enjoying him. Although his drama will always continue... he had developed a slight limp in his left front leg a couple months ago which he is still struggling with. The vet thinks he might have injured a shoulder ligament and since we are very cautious about using anesthesia for diagnosis we are not doing xrays at this time. Instead we have restricted his activities and giving it time to heal, expecting the healing to be slowed because of the pred usage. In fact, it may have been the pred that weakened his muscles making him more prone to injuries. It is a fine line any way you see it. Now since he is banned from chasing balls and frisbees which help with muscle tone, he is confined to walking only. He has gained a couple pounds putting more weight on the injured leg even though I've cut down on his calories. Then just when I think we're making a little progress he manages to gobble up a WHOLE LOAF of banana bread behind my back... aaaagggghhhh... so you get the picture...
One more new issue we are dealing with... he now has a ulcer in his left eye. Stopped pred acetate in that eye and are administrating two new serums and antibiotics... to be continued...
Meantime, a few recent photos of our beautiful Corkster:
a good looking eye:
a good looking nose:
Corky and Lulu... best buddies:
Monday, September 13, 2010
UPDATE Sept 10, 2010
Here's Corky today, feeling and looking great. He is on a maintenance of low doses of prednisone every other day along with the other supplements: Prednisone 10mg EOD alternated with 15mg EOD, azathioprine 50mg, doxycycline 100mg twice daily, niacinamide 500mg twice daily, Veterinary Immune Tabs 2 pro tabs daily 4x weekly, plus organic kelp powder daily.
Now that he is stabilized the next step is to slowly reduce the azathioprine and doxycyline. He will see the opthamologist this week and then his main vet for a check up and another thyroid test. Last lab results early August showed everything normal including all organs except the thyroid was very low at .4 (normal is 1 - 4). Although since he wasn't displaying typical hypo-thyroid symptoms we did not treat it. The vet said his low reading was extremely common for dogs undergoing intense prednisone treatment. If you review Corky's blog from March through July you will see the events of his relapse and the aggressive treatment we were forced to use.
As a result of the high dosages of prednisone during July, Corky suffered major side effects including shocking hair loss which is documented in the photos below. However, we were surprised at the speed of recovery as we expected extra slow hair regrowth due to the pred. This I lean toward crediting to the Vet Immune Tabs that he has been taking since the onset of symptoms back in December. At any rate, by early August it seemed the disease was back in remission, just prior our vacation to the High Sierra where we're originally from. We knew it would be a risk exposing Corky to the more intense ultra violet rays at high altitudes but I had made him a wardrobe of hats with visors and cooling coats to shade the bald spots all over his back and top of head. Well, right after our first fun hike with our long time friends and Cork's doggie buddies did he start to relapse with the same exact pattern of pigment fading across the nosebridge as what happened back in May (see earlier blog posts), along with a little blood from him rubbing his irritated nose against the grass. Okay, then... it didn't take long for me to discover that it is THE SUN! that triggers the symptoms. So, once I realized that I immediately modified his hat visors to extend beyond his nose and also decided to be vigilant about keeping that nose out of the sun for good. Which meant, sticking to shaded hikes, keeping those visors on him when in the sun, and continuing early morning and dusk walks. Once I realized that Corky is extremely sun sensitive I became adamant about his routines. And it worked.
Now, when he did begin to relapse second week of August I did what the eye doc suggested and backed up a step on the meds, meaning instead of every other day of pred I did every day at 20mg for a week. However, I was so nervous about a relapse like before that I decided to really stay on top of the process and hit him hard for one day at 30mg in the morning then 10mg in evening and tapper it down next day to 30mg, etc until we were back to 20mg daily. This course took 10 days. After that his nose pigment returned and we got back on the schedule of every other day 10mg alternated with 20mg. Today he is at 10mg EOD then 15mg EOD along with the other supplements and avoiding the sun. Whew! See below for photos of his hats. Double click photos to enlarge.
Sept 10, 2010:
July 23, 2010:
August 10, 2010
Sept 10, 2010:
May 27, 2010:
June 28, 2010:
Sept 10, 2010:
July 23, 2010:
Sept 10, 2010:
July 5, 2010:
July 29, 2010:
August 10, 2010:
Sept 10, 2010:
August 10, 2010: this hat covered his bald spot on his head and protected his eyes but the visor was too short to cover the nose so the sun aggravated it and triggered a relapse. Afterward I made extra long visors to shade his nose. Corky is also wearing a cooling coat to shade his bald spots. Needless to say he had a blast in the high country with his old pals.
These boots are made for walking and he loves them. They are by Ruffwear and have great traction and stay on. Best boots on market. His pads tend to get dry and cracked so I apply an organic foot balm then put his socks on before the boots. What a good sport!
Now that he is stabilized the next step is to slowly reduce the azathioprine and doxycyline. He will see the opthamologist this week and then his main vet for a check up and another thyroid test. Last lab results early August showed everything normal including all organs except the thyroid was very low at .4 (normal is 1 - 4). Although since he wasn't displaying typical hypo-thyroid symptoms we did not treat it. The vet said his low reading was extremely common for dogs undergoing intense prednisone treatment. If you review Corky's blog from March through July you will see the events of his relapse and the aggressive treatment we were forced to use.
As a result of the high dosages of prednisone during July, Corky suffered major side effects including shocking hair loss which is documented in the photos below. However, we were surprised at the speed of recovery as we expected extra slow hair regrowth due to the pred. This I lean toward crediting to the Vet Immune Tabs that he has been taking since the onset of symptoms back in December. At any rate, by early August it seemed the disease was back in remission, just prior our vacation to the High Sierra where we're originally from. We knew it would be a risk exposing Corky to the more intense ultra violet rays at high altitudes but I had made him a wardrobe of hats with visors and cooling coats to shade the bald spots all over his back and top of head. Well, right after our first fun hike with our long time friends and Cork's doggie buddies did he start to relapse with the same exact pattern of pigment fading across the nosebridge as what happened back in May (see earlier blog posts), along with a little blood from him rubbing his irritated nose against the grass. Okay, then... it didn't take long for me to discover that it is THE SUN! that triggers the symptoms. So, once I realized that I immediately modified his hat visors to extend beyond his nose and also decided to be vigilant about keeping that nose out of the sun for good. Which meant, sticking to shaded hikes, keeping those visors on him when in the sun, and continuing early morning and dusk walks. Once I realized that Corky is extremely sun sensitive I became adamant about his routines. And it worked.
Now, when he did begin to relapse second week of August I did what the eye doc suggested and backed up a step on the meds, meaning instead of every other day of pred I did every day at 20mg for a week. However, I was so nervous about a relapse like before that I decided to really stay on top of the process and hit him hard for one day at 30mg in the morning then 10mg in evening and tapper it down next day to 30mg, etc until we were back to 20mg daily. This course took 10 days. After that his nose pigment returned and we got back on the schedule of every other day 10mg alternated with 20mg. Today he is at 10mg EOD then 15mg EOD along with the other supplements and avoiding the sun. Whew! See below for photos of his hats. Double click photos to enlarge.
Sept 10, 2010:
July 23, 2010:
Sept 10, 2010:
May 27, 2010:
June 28, 2010:
Sept 10, 2010:
July 23, 2010:
Sept 10, 2010:
July 5, 2010:
July 29, 2010:
Sept 10, 2010:
Sept 10, 2010:
July 29, 2010:
August 10, 2010:
Sept 10, 2010:
August 10, 2010: this hat covered his bald spot on his head and protected his eyes but the visor was too short to cover the nose so the sun aggravated it and triggered a relapse. Afterward I made extra long visors to shade his nose. Corky is also wearing a cooling coat to shade his bald spots. Needless to say he had a blast in the high country with his old pals.
These boots are made for walking and he loves them. They are by Ruffwear and have great traction and stay on. Best boots on market. His pads tend to get dry and cracked so I apply an organic foot balm then put his socks on before the boots. What a good sport!
Sunday, August 1, 2010
SUMMARY August 1, 2010
Below are photos showing a brief course of events since the onset back in 2009. Corky relapsed in March while on a low maintenance dosage of prednisone 5mg every other day alternated with azathioprine along with niacinamide and prednisolone eyedrops twice daily. We continued the Veterinary Immue Tabs daily.
As the disease became more aggressive we gradually increased the pred but as the disease continued to be aggressive we had to get aggressive with the medication. During the whole month of June he was given up to 60mg pred for 18 days then gradually tappered to 30mg daily until his eye exams improved. He had seen the opthomologist three times that month. By July the pigment continued to return and the pred was reduced to 20mg daily. By mid July we were able to skip a day and go every other day at 20mg. We are now down to 20mg of pred EOD alternated with 10mg EOD. All other medications remain the same: azathioprine 50mg daily, niacinamide and doxycycline twice daily, prednisolone acetate 1% eyedrops twice daily, tropicamide eyedrops three times weekly. Vetinerinary Immune Tabs daily.
Corky's complete blood analysis came back with good results showing very normal organ levels except the thyroid read .4 (normal is between 1 - 4). The vet said this is typical of an animal on high medication. However, Corky does not have any clinical signs of hypo-thyroid symptoms so we will not treat it at this time. Instead we are gradually lowering the prednisone and will recheck the thyroid in 6 weeks. Meantime, Corky is full of energy and enjoying life.
As for the side effects of prednisone at high doses for the extended period Corky had the typical excessive thirst and urination, ravenous appetite, and hyper energy. He developed moist dermatitus and a rash on his belly which we treated with hydrocortisone cream and a cone around his neck to prevent him from licking. He had to wear the cone for weeks even after the rash cleared up. His paws became so dry and cracked sometimes he limped. I applied a natural organic foot balm to his paw pads and wrapped them in socks at night. During the day on our hikes he wore boots and socks made by Ruff Wear, the best on the market. He could run and chase balls without the boots coming off and he actually seemed to like wearing them. Now he doesn't need to wear them anymore. It took continuous effort to soften his paws and at the same time exercise him enough in order to keep his muscles toned since the pred weakens muscles. In the long run we did notice muscle loss with a slight swayback. It would've been much worse if he didn't get adequate exercise but he hikes every day with us, chases balls and frisbees and swims in the lap pool.
The cracks at his nostrils bled occasionally during the drug therapy but once blood poured from his left nostril on a hot day. Luckily it didn't last long and didn't happen again. Because the pred thinned his skin he bleeds more easily. One day on our morning hike he rubbed himself hard against a nasty thorn bush which left deep scratches on top his head and along his back. Although these scratches bled more than normal we didn't notice them until the next day after they scabbed. The scabs dried up, he kept rolling on his back to relieve the itch, the scabs came off along with the hairs. To our horror, he ended up a patchwork of big bald spots all over his body. At this time I cannot bring myself to post the photos but when the hairs all grow back I'll show before and afters. To our relief the hairs are growing back nicely though we expected a very slow process due to the pred. Perhaps the Vet Immune Tabs made the difference. Corky now has a whole wardrobe of hats and cooling coats he must wear everyday when outside. Luckily he is a good sport and wears anything I put on him.
All in all we are on an uphill of the rollercoaster. The disease seems to be back in remission. Slowly we are decreasing the pred but will not go as low as before the second episode. Meantime, Corky is having a good life full of fun and lots of love.
As the disease became more aggressive we gradually increased the pred but as the disease continued to be aggressive we had to get aggressive with the medication. During the whole month of June he was given up to 60mg pred for 18 days then gradually tappered to 30mg daily until his eye exams improved. He had seen the opthomologist three times that month. By July the pigment continued to return and the pred was reduced to 20mg daily. By mid July we were able to skip a day and go every other day at 20mg. We are now down to 20mg of pred EOD alternated with 10mg EOD. All other medications remain the same: azathioprine 50mg daily, niacinamide and doxycycline twice daily, prednisolone acetate 1% eyedrops twice daily, tropicamide eyedrops three times weekly. Vetinerinary Immune Tabs daily.
Corky's complete blood analysis came back with good results showing very normal organ levels except the thyroid read .4 (normal is between 1 - 4). The vet said this is typical of an animal on high medication. However, Corky does not have any clinical signs of hypo-thyroid symptoms so we will not treat it at this time. Instead we are gradually lowering the prednisone and will recheck the thyroid in 6 weeks. Meantime, Corky is full of energy and enjoying life.
As for the side effects of prednisone at high doses for the extended period Corky had the typical excessive thirst and urination, ravenous appetite, and hyper energy. He developed moist dermatitus and a rash on his belly which we treated with hydrocortisone cream and a cone around his neck to prevent him from licking. He had to wear the cone for weeks even after the rash cleared up. His paws became so dry and cracked sometimes he limped. I applied a natural organic foot balm to his paw pads and wrapped them in socks at night. During the day on our hikes he wore boots and socks made by Ruff Wear, the best on the market. He could run and chase balls without the boots coming off and he actually seemed to like wearing them. Now he doesn't need to wear them anymore. It took continuous effort to soften his paws and at the same time exercise him enough in order to keep his muscles toned since the pred weakens muscles. In the long run we did notice muscle loss with a slight swayback. It would've been much worse if he didn't get adequate exercise but he hikes every day with us, chases balls and frisbees and swims in the lap pool.
The cracks at his nostrils bled occasionally during the drug therapy but once blood poured from his left nostril on a hot day. Luckily it didn't last long and didn't happen again. Because the pred thinned his skin he bleeds more easily. One day on our morning hike he rubbed himself hard against a nasty thorn bush which left deep scratches on top his head and along his back. Although these scratches bled more than normal we didn't notice them until the next day after they scabbed. The scabs dried up, he kept rolling on his back to relieve the itch, the scabs came off along with the hairs. To our horror, he ended up a patchwork of big bald spots all over his body. At this time I cannot bring myself to post the photos but when the hairs all grow back I'll show before and afters. To our relief the hairs are growing back nicely though we expected a very slow process due to the pred. Perhaps the Vet Immune Tabs made the difference. Corky now has a whole wardrobe of hats and cooling coats he must wear everyday when outside. Luckily he is a good sport and wears anything I put on him.
All in all we are on an uphill of the rollercoaster. The disease seems to be back in remission. Slowly we are decreasing the pred but will not go as low as before the second episode. Meantime, Corky is having a good life full of fun and lots of love.
Eyes summary
August 1, 2010:
June 28, 2010:
May 31, 2010:
March 20, 2010:
June 28, 2010:
May 31, 2010:
March 20, 2010:
February 9, 2010:
January 19, 2010:
December 8, 2009:
January 19, 2010:
December 8, 2009:
Nosebridge summary
August 1, 2010:
June 28, 2010:
May 31, 2010:
February 9, 2010:
January 19, 2010:
December 8, 2009:
June 28, 2010:
May 31, 2010:
February 9, 2010:
January 19, 2010:
December 8, 2009:
Thursday, July 29, 2010
Lips & nostrils summary
August 1, 2010: smoother with cobblestone texture. Full pigmentation.
June 28, 2010: loss of cobblestone texture, cracks around nostrils that often bled.
May 31, 2010:
February 9, 2010:
January 19, 2010:
January 19, 2010: After several weeks of initial treatment and maintenance of 5mg pred every other day alternated with azathioprine. See earliest posts for complete med program.
December 8, 2009: Just biopsied and diagnosed as UVD. On the surface the disease attacks the margins at mucous membranes where pigment meets hairline; the lips, nose bridge, eyerims, paws, anus. Internally it also attacks the eye retina and nostrils and other mucous membranes. Here, prior correct treatment, Corky lost all black pigment on his lips:
June 28, 2010: loss of cobblestone texture, cracks around nostrils that often bled.
May 31, 2010:
February 9, 2010:
January 19, 2010:
December 8, 2009:
August 1, 2010: Complete return of pigmentation. Continued lowering of prednisone dosage. Every other day pred 20mg / skip a day / pred 10mg / skip / pred 20mg/ skip / pred 10 mg... Next step will be pred 15mg EOD then gradually 10mg EOD. All other meds and eyedrops remain the same.
June 28, 2010: After intense period of aggressive medication to put the disease back into remission. See earlier posts for medication routine.
May 31, 2010: at the start of the aggressive medication approach as the disease became more aggressive:
March 20, 2010: Relapse mid March. Increased pred from 5mg to 10mg for several weeks at no avail.
February 9, 2010: Continued improvement and stabilization with low doses of prednisone 5mg every other day alternated with azathioprine. Con't with niacinamide and Veterinary Immune Tabs daily. See earliest posts for complete medication program.
January 19, 2010: After several weeks of initial treatment and maintenance of 5mg pred every other day alternated with azathioprine. See earliest posts for complete med program.
December 8, 2009: Just biopsied and diagnosed as UVD. On the surface the disease attacks the margins at mucous membranes where pigment meets hairline; the lips, nose bridge, eyerims, paws, anus. Internally it also attacks the eye retina and nostrils and other mucous membranes. Here, prior correct treatment, Corky lost all black pigment on his lips:
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