Monday, September 13, 2010

UPDATE Sept 10, 2010


Here's Corky today, feeling and looking great. He is on a maintenance of low doses of prednisone every other day along with the other supplements: Prednisone 10mg EOD alternated with 15mg EOD, azathioprine 50mg, doxycycline 100mg twice daily, niacinamide 500mg twice daily, Veterinary Immune Tabs 2 pro tabs daily 4x weekly, plus organic kelp powder daily.

Now that he is stabilized the next step is to slowly reduce the azathioprine and doxycyline. He will see the opthamologist this week and then his main vet for a check up and another thyroid test. Last lab results early August showed everything normal including all organs except the thyroid was very low at .4 (normal is 1 - 4). Although since he wasn't displaying typical hypo-thyroid symptoms we did not treat it. The vet said his low reading was extremely common for dogs undergoing intense prednisone treatment. If you review Corky's blog from March through July you will see the events of his relapse and the aggressive treatment we were forced to use.

As a result of the high dosages of prednisone during July, Corky suffered major side effects including shocking hair loss which is documented in the photos below. However, we were surprised at the speed of recovery as we expected extra slow hair regrowth due to the pred. This I lean toward crediting to the Vet Immune Tabs that he has been taking since the onset of symptoms back in December. At any rate, by early August it seemed the disease was back in remission, just prior our vacation to the High Sierra where we're originally from. We knew it would be a risk exposing Corky to the more intense ultra violet rays at high altitudes but I had made him a wardrobe of hats with visors and cooling coats to shade the bald spots all over his back and top of head. Well, right after our first fun hike with our long time friends and Cork's doggie buddies did he start to relapse with the same exact pattern of pigment fading across the nosebridge as what happened back in May (see earlier blog posts), along with a little blood from him rubbing his irritated nose against the grass. Okay, then... it didn't take long for me to discover that it is THE SUN! that triggers the symptoms. So, once I realized that I immediately modified his hat visors to extend beyond his nose and also decided to be vigilant about keeping that nose out of the sun for good. Which meant, sticking to shaded hikes, keeping those visors on him when in the sun, and continuing early morning and dusk walks. Once I realized that Corky is extremely sun sensitive I became adamant about his routines. And it worked.
Now, when he did begin to relapse second week of August I did what the eye doc suggested and backed up a step on the meds, meaning instead of every other day of pred I did every day at 20mg for a week. However, I was so nervous about a relapse like before that I decided to really stay on top of the process and hit him hard for one day at 30mg in the morning then 10mg in evening and tapper it down next day to 30mg, etc until we were back to 20mg daily. This course took 10 days. After that his nose pigment returned and we got back on the schedule of every other day 10mg alternated with 20mg. Today he is at 10mg EOD then 15mg EOD along with the other supplements and avoiding the sun. Whew! See below for photos of his hats. Double click photos to enlarge.

Sept 10, 2010:

July 23, 2010:

August 10, 2010


Sept 10, 2010:

May 27, 2010:


June 28, 2010:


Sept 10, 2010:


July 23, 2010:


Sept 10, 2010:

July 5, 2010:


July 29, 2010:

Sept 10, 2010:


July 29, 2010:


August 10, 2010:


Sept 10, 2010:

August 10, 2010: this hat covered his bald spot on his head and protected his eyes but the visor was too short to cover the nose so the sun aggravated it and triggered a relapse. Afterward I made extra long visors to shade his nose. Corky is also wearing a cooling coat to shade his bald spots. Needless to say he had a blast in the high country with his old pals.






These boots are made for walking and he loves them. They are by Ruffwear and have great traction and stay on. Best boots on market. His pads tend to get dry and cracked so I apply an organic foot balm then put his socks on before the boots. What a good sport!

Sunday, August 1, 2010

SUMMARY August 1, 2010


Below are photos showing a brief course of events since the onset back in 2009. Corky relapsed in March while on a low maintenance dosage of prednisone 5mg every other day alternated with azathioprine along with niacinamide and prednisolone eyedrops twice daily. We continued the Veterinary Immue Tabs daily.

As the disease became more aggressive we gradually increased the pred but as the disease continued to be aggressive we had to get aggressive with the medication. During the whole month of June he was given up to 60mg pred for 18 days then gradually tappered to 30mg daily until his eye exams improved. He had seen the opthomologist three times that month. By July the pigment continued to return and the pred was reduced to 20mg daily. By mid July we were able to skip a day and go every other day at 20mg. We are now down to 20mg of pred EOD alternated with 10mg EOD. All other medications remain the same: azathioprine 50mg daily, niacinamide and doxycycline twice daily, prednisolone acetate 1% eyedrops twice daily, tropicamide eyedrops three times weekly. Vetinerinary Immune Tabs daily.

Corky's complete blood analysis came back with good results showing very normal organ levels except the thyroid read .4 (normal is between 1 - 4). The vet said this is typical of an animal on high medication. However, Corky does not have any clinical signs of hypo-thyroid symptoms so we will not treat it at this time. Instead we are gradually lowering the prednisone and will recheck the thyroid in 6 weeks. Meantime, Corky is full of energy and enjoying life.

As for the side effects of prednisone at high doses for the extended period Corky had the typical excessive thirst and urination, ravenous appetite, and hyper energy. He developed moist dermatitus and a rash on his belly which we treated with hydrocortisone cream and a cone around his neck to prevent him from licking. He had to wear the cone for weeks even after the rash cleared up. His paws became so dry and cracked sometimes he limped. I applied a natural organic foot balm to his paw pads and wrapped them in socks at night. During the day on our hikes he wore boots and socks made by Ruff Wear, the best on the market. He could run and chase balls without the boots coming off and he actually seemed to like wearing them. Now he doesn't need to wear them anymore. It took continuous effort to soften his paws and at the same time exercise him enough in order to keep his muscles toned since the pred weakens muscles. In the long run we did notice muscle loss with a slight swayback. It would've been much worse if he didn't get adequate exercise but he hikes every day with us, chases balls and frisbees and swims in the lap pool.

The cracks at his nostrils bled occasionally during the drug therapy but once blood poured from his left nostril on a hot day. Luckily it didn't last long and didn't happen again. Because the pred thinned his skin he bleeds more easily. One day on our morning hike he rubbed himself hard against a nasty thorn bush which left deep scratches on top his head and along his back. Although these scratches bled more than normal we didn't notice them until the next day after they scabbed. The scabs dried up, he kept rolling on his back to relieve the itch, the scabs came off along with the hairs. To our horror, he ended up a patchwork of big bald spots all over his body. At this time I cannot bring myself to post the photos but when the hairs all grow back I'll show before and afters. To our relief the hairs are growing back nicely though we expected a very slow process due to the pred. Perhaps the Vet Immune Tabs made the difference. Corky now has a whole wardrobe of hats and cooling coats he must wear everyday when outside. Luckily he is a good sport and wears anything I put on him.

All in all we are on an uphill of the rollercoaster. The disease seems to be back in remission. Slowly we are decreasing the pred but will not go as low as before the second episode. Meantime, Corky is having a good life full of fun and lots of love.

Eyes summary

August 1, 2010:



June 28, 2010:


May 31, 2010:


March 20, 2010:



February 9, 2010:


January 19, 2010:


December 8, 2009:










Nosebridge summary

August 1, 2010:



June 28, 2010:


May 31, 2010:


February 9, 2010:


January 19, 2010:


December 8, 2009:








Thursday, July 29, 2010

Lips & nostrils summary

August 1, 2010: smoother with cobblestone texture. Full pigmentation.



June 28, 2010: loss of cobblestone texture, cracks around nostrils that often bled.

May 31, 2010:



February 9, 2010:


January 19, 2010:


December 8, 2009:






August 1, 2010: Complete return of pigmentation. Continued lowering of prednisone dosage. Every other day pred 20mg / skip a day / pred 10mg / skip / pred 20mg/ skip / pred 10 mg... Next step will be pred 15mg EOD then gradually 10mg EOD. All other meds and eyedrops remain the same.



June 28, 2010: After intense period of aggressive medication to put the disease back into remission. See earlier posts for medication routine.


May 31, 2010: at the start of the aggressive medication approach as the disease became more aggressive:




March 20, 2010: Relapse mid March. Increased pred from 5mg to 10mg for several weeks at no avail.



February 9, 2010: Continued improvement and stabilization with low doses of prednisone 5mg every other day alternated with azathioprine. Con't with niacinamide and Veterinary Immune Tabs daily. See earliest posts for complete medication program.


January 19, 2010: After several weeks of initial treatment and maintenance of 5mg pred every other day alternated with azathioprine. See earliest posts for complete med program.

December 8, 2009: Just biopsied and diagnosed as UVD. On the surface the disease attacks the margins at mucous membranes where pigment meets hairline; the lips, nose bridge, eyerims, paws, anus. Internally it also attacks the eye retina and nostrils and other mucous membranes. Here, prior correct treatment, Corky lost all black pigment on his lips:

Tuesday, July 6, 2010

JULY 6TH, 2010 HAPPY BIRTHDAY CORKY!

Today he turned 7! Isn't he gorgeous! Today is a good day!

Luckily you can't see the bald spots except for the one on his front leg. More on the pred side effects later. For now we are celebrating his happy day. Today he is full of life and loves his new birthday ball. Simple things...


Monday, July 5, 2010

July 5, 2010

Here is a quick update for now... photos before we started the intense therapy course and after. Scroll down to earlier posts for details of medication adjustments and more photos. We have tappered the prednisone down from 60mg for 18 days then 40mg 10 days, 30mg 10 days, and are now down to 20mg per day. All other meds remained the same. We are aiming to get him on an every other day maintenence schedule again. I will update after the next eye exam in a few days and also comment on the side effects of the high dosages. He is still full of energy and still has a great attitude. He is just the best sport ever. I hate to see him as the poster dog for this disease but if this blog could help someone else, here it is. We are thrilled to be able to celebrate his 7th birthday tomorrow. Today he had a fun hike along his favorite trail up Mt Lemmon with the family and tomorrow he'll get to party more... Every day is precious. Did I say how much I love him?...

More later, for now here's a comparison of the pigment changes since May 23:

July 5, 2010:

May 23, 2010:

July 5, 2010:

May 23, 2010:


July 5, 2010:
May 23, 2010:
July 5, 2010: Notice the hyperpigmentation in a place he never had pigment before. It is not consistent this time around:
May 23, 2010: