Saturday, July 16, 2011

Definition repeat from older post:

Uveodermatological Syndrome:

Uveodermatological Syndrome (UDS) is an immune-mediated canine disease characterized by inflammation of the eye, depigmentation of skin and whitening of hair. Morbidity is related primarily to the eye inflammation, which can result in secondary ophthalmological disorders that lead to blindness. Treatment involves both topical and systemic immunosuppression. It is believed that UDS results from a genetic flaw, and as yet there is no cure.

Uveodermatological Syndrome is similar to the human Vogt-Koyanagi-Haradi Syndrome (VKH), was first described in 1977. Human VKH is characterized by uveitis (inflammation of the eye), poliosis (whitening of hair), vitiligo (depigmentation of skin) and a variety of neurological symptoms. Unlike VKH, however, UDS does not usually present with neurological symptoms. Because of the similarity of the two entities, UDS is sometimes referred to as VKH-like Syndrome or simply VKH. Although generally considered to be more common in Northern breeds, such as Akitas, Siberians and Samoyeds, there have been reports of the disease in a wide range of breeds, including the Australian Shepherd, Dachshund, Brazilian Fila dog.

Clinical Relevance: Some breeds in which uveodermatologic syndrome has been reported (eg, Siberian Huskies, Old English Sheepdogs, Australian Shepherds, and Shetland Sheepdogs) often have heterochromia irides. This case highlights the fact that dogs with asymmetric uveal pigmentation may have unilateral ocular changes; therefore, uveodermatologic syndrome should not be excluded as a differential diagnosis on the basis of unilateral clinical signs.

Here are links to good documentations of dogs with the disease:

Friday, July 8, 2011

July 6, 2011 CORKY TURNS 8!!!

Corky remains stable and happy and we have been enjoying a long remission of the disease... however the symptoms do try to sneak up at times and then I will increase the dosage of pred a bit following a gradual tapering until we are back to the EOD (every other day) routine. I watch for symptoms mainly of pigment recession around the eyerims, nose, and mouth and also for any squinting. When the black pigment starts to fade to pink, usually at the eye corners, I increase the dosage to 20mg prednisone for one day then decrease it to 15mg for the next two or three along with all the other meds until we get back to the EOD schedule.
Last eye exams were good and improved since we switched from regular prednisolone acetate drops to pred mild drops every other day. He only has to see the opthamologist every 4 months now. Cork's recent full body lab results showed normal ranges in all organs except now the liver is showing some steroids. This did not surprise the doctor but he had expected to see this kind of result many months ago as Corky has been under steroid therapy for 19 months. The doctor was simply amazed. I wondered if Cork's success can be credited to the long term use of the Veterinary Immune Tabs that have Transfer Factors and medicinal mushroom extracts. At any rate his thyroid is doing fine and overall Corky looks fantastic! His coat is thick and healthy, the black pigment around his face looks great, his musculature is great, paw pads have greatly improved, and even the limp is gone. As for the liver, we have added "SAMe" s-adenosyl 225mg/ milk thistle to his routine in order to protect the liver.
Here is Corky's current meds: Azathioprine 50mg once daily, niacinamide 500mg & doxycycline 100mg & SAMe 225mg & thyroxine .4mg twice daily. Prednisone 10mg or 12.5mg once every other day. Prednisolone mild acetate 12% eyedrops in both eyes once every other day. Genteal mild eyedrops twice daily. Veterinary Immune Tabs professional strength 2 tabs 4 times weekly. Taste of the Wild salmon/sweet potato kibble and spoonfuls of Naturals fish/sweet potato canned and/or fresh salmon, carrots, apple, treats. Also, to support his thyroid he gets 1 tsp organic kelp powder daily. Most important ingredient of all: unconditional endless LOVE!
During Corky's rehab for his front leg limp he swam many laps in the pool. The limp lasted about 6 months. Finally I restricted his daily walks to absolute minimum with no running but increased his swimming sessions. One day he suddenly stopped limping and hasn't limped since. Here he is going for a swim... fetching the ball in the long lap pool: